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Colistin (Polymyxin E) is a bactericidal antibiotic that works by disrupting the bacterial outer cell membrane, causing leakage of essential cell components and rapid bacterial death. COLICULT-1 Injection is formulated for parenteral administration and provides strong activity against difficult-to-treat gram-negative pathogens, especially those resistant to carbapenems, cephalosporins, and other antibiotics. Due to its potency, this medication is administered only under strict medical supervision, with careful monitoring of kidney and neurological functions. Uses (Indications) COLICULT-1 Injection is indicated for the treatment of severe infections caused by susceptible gram-negative bacteria, especially when other antibiotics fail. Common clinical uses include: ✅ Respiratory Tract Infections Hospital-acquired pneumonia Ventilator-associated pneumonia (VAP) ✅ Bloodstream Infections Septicemia Bacteremia ✅ Urinary Tract Infections Complicated UTIs Pyelonephritis ✅ Intra-abdominal Infections Peritonitis Post-surgical infections ✅ Skin & Soft Tissue Infections Wound infections Burns Surgical site infections ✅ Meningitis (selected cases) ✅ Multidrug-Resistant Infections Carbapenem-resistant infections ICU-related infections Nosocomial infections
